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Coming up with brand new drugs is all about pinpointing and exploiting a disease’s weakness. A big part of perfecting drug design will be learning to predict how proteins get their shapes because that has everything to do with how both diseases and drugs work.
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Sources:
https://www.pbs.org/newshour/health/the-real-story-behind-the-worlds-first-antibiotic
https://www.cancer.gov/research/progress/discovery/gleevec
https://www.nature.com/scitable/topicpage/gleevec-the-breakthrough-in-cancer-treatment-565
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238551/
https://www.ncbi.nlm.nih.gov/pubmed/17921997
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889822/
http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=69B25B99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138819/pdf/gb-2000-1-1-comment002.pdf
https://science.sciencemag.org/content/294/5540/93
https://www.biostat.wisc.edu/bmi776/lectures/Rosetta.pdf
https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25415
https://commons.wikimedia.org/wiki/File:TOP7-rosetta_superposition.png
https://commons.wikimedia.org/wiki/File:HSQC-NMR.tiff
https://commons.wikimedia.org/wiki/File:X-ray_diffraction_pattern_3clpro.jpg
https://www.nature.com/articles/nrd941
https://commons.wikimedia.org/wiki/File:Spombe_Pop2p_protein_structure_rainbow.png
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1186895/
https://www.ncbi.nlm.nih.gov/books/NBK22393/
https://academic.oup.com/bioinformatics/article/23/6/717/418732
Image Sources:
https://en.wikipedia.org/wiki/Amino_acid#/media/File:Amino_Acids.svg
https://commons.wikimedia.org/wiki/File:Imatinib_xtal-2007-balls-and-sticks.png
https://commons.wikimedia.org/wiki/File:Bruker_Avance_DPX_250_NMR_Spectrometer.jpg
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