Testing new treatments in other animals can help us spot complications or potential pitfalls, but the results don’t always carry over to humans, which means that safely going from animal to human trials is a lot more complicated than you might think.
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Sources:
https://www.fda.gov/ForPatients/Approvals/Drugs/default.htm
https://www.aphis.usda.gov/animal_welfare/downloads/reports/Annual-Report-Animal-Usage-by-FY2017.pdf
http://www.the-aps.org/mm/SciencePolicy/AnimalResearch/Publications/animals/quest5.htm
https://academic.oup.com/ilarjournal/article/41/3/133/708856
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782548/
http://ko.cwru.edu/info/breeding_strategies_manual.pdf
https://link.springer.com/article/10.1007/s00228-018-02607-8
https://www.ncbi.nlm.nih.gov/pubmed/19896825
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020770/
https://www.ncbi.nlm.nih.gov/books/NBK224550/
https://www.aalas.org/iacuc/laws-policies-guidelines/international-government
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782548/
https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.105.594945?url_ver=Z39.88-2003&rfr_id=oriridcrossref.org&rfr_dat=cr_pubpubmed&