In the previous episode we discussed what happens when we use electrophilic aromatic substitution to add a group to a benzene ring, but what happens when you try to add even more groups? Well, things get a little more complicated. In this episode of Crash Course Organic Chemistry, we’ll continue our exploration of EAS reactions by looking at electron donating groups and electron withdrawing groups on benzene, and how they affect what happens when we try to add new groups to the ring.
Episode Sources:
Hammond, G.S. and Douglas, K.J., 1959. Aromatic nitration. III. The ortho to para ratio in nitration of benzonitrile. Journal of the American Chemical Society, 81(5), pp.1184-1187.
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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